Ashley I Bush Selected Research

Ceruloplasmin (Ferroxidase)

1/2021	Acute phase markers in CSF reveal inflammatory changes in Alzheimer's disease that intersect with pathology, APOE ε4, sex and age.
1/2020	Cerebrospinal fluid ceruloplasmin levels predict cognitive decline and brain atrophy in people with underlying β-amyloid pathology.
1/2017	Oxidation of Iron under Physiologically Relevant Conditions in Biological Fluids from Healthy and Alzheimer's Disease Subjects.
4/2014	Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron.
1/2014	Meta-analysis of serum non-ceruloplasmin copper in Alzheimer's disease.
4/2013	Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease.
1/2013	Longitudinal analysis of serum copper and ceruloplasmin in Alzheimer's disease.
1/2012	Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.
9/2010	Iron-export ferroxidase activity of β-amyloid precursor protein is inhibited by zinc in Alzheimer's disease.
5/2009	Copper transport into the secretory pathway is regulated by oxygen in macrophages.

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Ashley I Bush Research Topics

Disease

180	Alzheimer Disease (Alzheimer's Disease) 11/2022 - 05/2002
46	Cognitive Dysfunction 04/2022 - 10/2004
36	Neurodegenerative Diseases (Neurodegenerative Disease) 04/2022 - 04/2004
32	Parkinson Disease (Parkinson's Disease) 01/2022 - 03/2003
20	Amyloid Plaque 01/2018 - 04/2003
14	Schizophrenia (Dementia Praecox) 01/2020 - 08/2008
12	Dementia (Dementias) 04/2022 - 04/2004
10	Huntington Disease (Huntington's Disease) 01/2021 - 03/2007
10	Bipolar Disorder (Manic Depressive Psychosis) 12/2018 - 09/2008
9	Atrophy 01/2020 - 01/2012
8	Disease Progression 04/2022 - 12/2004
8	Inflammation (Inflammations) 01/2022 - 07/2011
7	Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) 01/2021 - 09/2004
7	Neuroblastoma 04/2014 - 11/2002
6	Tauopathies 04/2022 - 01/2012
6	Iron Overload 04/2022 - 01/2016
6	Stroke (Strokes) 10/2021 - 12/2005
6	Mental Disorders (Mental Disorder) 01/2020 - 07/2008
5	Neoplasms (Cancer) 01/2022 - 05/2015
5	Neuroinflammatory Diseases 01/2022 - 11/2012
5	Parkinsonian Disorders (Parkinsonism) 10/2020 - 01/2012
3	Acute-Phase Reaction 01/2022 - 01/2020
3	Brain Ischemia (Cerebral Ischemia) 01/2022 - 01/2017
3	Cardiovascular Diseases (Cardiovascular Disease) 11/2021 - 09/2005
3	Ischemia 10/2021 - 04/2004
3	Proteostasis Deficiencies 01/2021 - 10/2014
3	Frontotemporal Dementia (Semantic Dementia) 11/2020 - 01/2018
3	Body Weight (Weight, Body) 01/2020 - 11/2012
3	Necrosis 12/2018 - 05/2009
3	Nervous System Diseases (Neurological Disorders) 01/2017 - 11/2011
3	Mitochondrial Diseases (Mitochondrial Disease) 11/2016 - 06/2007
3	Hypoxia (Hypoxemia) 12/2014 - 12/2005
3	Amyloidosis 05/2009 - 12/2004
2	Multiple System Atrophy 01/2022 - 11/2021
2	Friedreich Ataxia (Friedreich's Ataxia) 12/2021 - 01/2021
2	Hepatolenticular Degeneration (Wilson's Disease) 11/2021 - 01/2021
2	Synucleinopathies 11/2021 - 01/2016
2	Reperfusion Injury 10/2021 - 01/2021
2	Ischemic Stroke 10/2021 - 01/2017
2	Pantothenate Kinase-Associated Neurodegeneration (Hallervorden-Spatz Disease) 01/2021 - 01/2019
2	Type C Niemann-Pick Disease (Niemann Pick Disease, Type C) 01/2020 - 03/2014
2	Weight Loss (Weight Reduction) 01/2019 - 01/2013
2	Acrodermatitis enteropathica 01/2019 - 01/2013
2	Dyskinesias (Dyskinesia) 10/2018 - 05/2013

Drug/Important Bio-Agent (IBA)

75	IronIBA 11/2022 - 11/2002
62	Amyloid (Amyloid Fibrils)IBA 01/2021 - 04/2003
53	Amyloid beta-PeptidesIBA 01/2021 - 05/2002
52	CopperIBA 01/2022 - 10/2002
50	Proteins (Proteins, Gene)FDA Link 04/2022 - 04/2003
41	MetalsIBA 01/2022 - 11/2002
38	Biomarkers (Surrogate Marker)IBA 11/2022 - 05/2004
35	ZincIBA 01/2021 - 07/2003
22	Peptides (Polypeptides)IBA 01/2020 - 08/2002
15	IonsIBA 01/2018 - 01/2003
12	Apolipoproteins E (ApoE)IBA 11/2022 - 12/2010
11	AntioxidantsIBA 01/2019 - 01/2005
11	Cysteine (L-Cysteine)FDA Link 12/2018 - 07/2006
10	Ceruloplasmin (Ferroxidase)IBA 01/2021 - 05/2009
9	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2022 - 06/2005
9	Glutathione (Reduced Glutathione)IBA 12/2021 - 07/2008
9	Trace Elements (Biometals)IBA 10/2017 - 03/2004
9	Pharmaceutical PreparationsIBA 01/2017 - 08/2002
9	Acetylcysteine (Siran)FDA LinkGeneric 12/2015 - 07/2008
8	LipidsIBA 11/2022 - 01/2003
8	Biological ProductsIBA 11/2021 - 01/2009
8	Clioquinol (Vioform)FDA Link 01/2019 - 11/2002
7	Ferritins (Ferritin)IBA 01/2022 - 12/2008
7	CholesterolIBA 01/2020 - 01/2003
6	SeleniumIBA 01/2022 - 11/2014
6	EnzymesIBA 01/2022 - 05/2009
6	Chelating AgentsIBA 11/2021 - 11/2002
6	tau Proteins (tau Protein)IBA 10/2017 - 11/2010
5	ApolipoproteinsIBA 11/2022 - 12/2010
5	Messenger RNA (mRNA)IBA 01/2022 - 08/2002
5	polyglutamineIBA 01/2015 - 03/2007
4	DeferiproneIBA 01/2022 - 01/2020
4	alpha-SynucleinIBA 09/2021 - 01/2016
4	UbiquitinIBA 01/2020 - 01/2014
4	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2020 - 01/2014
4	IonophoresIBA 01/2019 - 01/2010
4	Levodopa (L Dopa)FDA LinkGeneric 01/2019 - 05/2013
4	Brain-Derived Neurotrophic Factor (BDNF)IBA 12/2018 - 11/2013
4	Superoxide Dismutase-1IBA 06/2014 - 09/2004
3	PresenilinsIBA 11/2022 - 03/2011
3	Blood Proteins (Serum Proteins)IBA 01/2022 - 01/2017
3	zinc-binding protein (zinc binding protein)IBA 01/2020 - 01/2013
3	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2018 - 11/2010
3	Huntingtin ProteinIBA 01/2017 - 03/2007
3	dityrosineIBA 01/2017 - 01/2004
3	Vitamin B 12 (Cyanocobalamin)FDA LinkGeneric 01/2014 - 01/2011
3	Superoxide DismutaseIBA 05/2009 - 10/2002
2	8-hydroxyquinazolin-4(3H)-oneIBA 09/2021 - 01/2017
2	SynucleinsIBA 12/2020 - 03/2016
2	Selenic AcidIBA 11/2020 - 01/2019
2	Carrier Proteins (Binding Protein)IBA 04/2020 - 11/2012
2	Isoflurophate (DFP)FDA Link 01/2020 - 01/2020
2	Methionine (L-Methionine)FDA Link 01/2020 - 05/2004
2	Dopamine (Intropin)FDA LinkGeneric 01/2019 - 05/2013
2	ManganeseIBA 12/2018 - 01/2016

Therapy/Procedure

23	Therapeutics 01/2022 - 08/2002